Endocrine Abstracts

Background: The Insulin Tolerance Test (ITT) is the gold standard for assessing pituitary function in adults, but used variably in paediatrics due to concerns of serious adverse events. Our aim was to assess the safety of ITT and identify factors associated with the hypoglycaemic response.Methods: We retrospectively collected the following data from patients who underwent ITT (n=122) under Paediatric Endocrinology from 2019-2021: demography, ant...

Introduction: Approximately 3200 children and young people in the UK receive GH therapy. Currently 12 different GH injection devices are available, with NHS guidance (NICE-TA188) recommending that patients/carers should have a choice of product. Whilst there is evidence that offering such choice may improve treatment adherence, little is known about its importance to patients/carers, nor whether device preferences should be reviewed after a period of treatment.<p class="ab...

Background: The short synacthen test (SST) is commonly used to evaluate the integrity of the hypothalamic–pituitary–adrenal (HPA) axis in children. However, this test is time-consuming, requiring cannulation, several blood samples, and medical observation. Studies in adults have suggested an early morning serum cortisol level could be used to rule out or confirm adrenal insufficiency, reducing reliance on SSTs, however, few studies have evaluated thi...